Applicability of heart rate variability for cardiac autonomic assessment in long-term COVID patients: A systematic review.

PURPOSE: To carry out a systematic review to determine the main methods used to study the heart rate variability (HRV) in individuals after the acute phase of COVID-19. METHODS: The study followed the Preferred Items for Reporting for Systematic Reviews and Meta-Analyses (PRISMA) statement. PubMed, Web of Science, Scopus and CINAHAL electronic databases were searched from the inception to November 2022. The studies were included if they used HRV assessment based on linear and non-linear methods in long-term COVID-19 patients. Review studies, theses and dissertations, conference abstracts, longitudinal studies, studies conducted on animals and studies that included individuals in the acute phase of the COVID-19 were excluded. The methodological quality of the studies was analyzed using the Joanna Briggs Institute's critical evaluation checklist for cross-sectional analytical studies. RESULTS: HRV was mainly assessed using 24-h Holter monitoring in 41.6% (5/12) of the studies, and 12­lead ECG was used in 33.3% (4/12). Regarding the type of assessment, 66.6% (8/12) of the studies only used linear analysis, where 25% (3/12) used analysis in the time domain, and 41.6% (5/12) used both types. Non-linear methods were combined with the previously cited linear method in 25% (3/12) of the studies. Moreover, 50% (6/12) of the studies demonstrated post-COVID-19 autonomic dysfunction, with an increase in the predominance of cardiac sympathetic modulation. The average score of the evaluation checklist was 6.6, characterized as having reasonable methodological quality. CONCLUSION: 24-h Holter and 12­lead ECG are considered effective tools to assess HRV in post-COVID-19 patients. Furthermore, the findings reveal diverse effects of COVID-19 on the autonomic nervous system's sympathovagal balance, which might be influenced by secondary factors such as disease severity, patients' overall health, evaluation timing, post-infection complications, ventilatory functions, and age.

A validation study of a smartphone application for heart rate variability assessment in asymptomatic adults.

BACKGROUND: Assessment of heart rate variability (HRV) is an effective non-invasive tool to obtain data on cardiac autonomic modulation and may be assessed by a range of devices, including mobile applications. Objective: This study aimed to validate a smartphone application by comparing the R-R intervals (RRi) obtained by the app with a classic electrocardiogram (ECG)-derived reference condition Methods: Fifteen asymptomatic adults (24.9±3.4 years) underwent an orthostatic challenge during which RRi were simultaneously recorded by a freeware smartphone application and by an ECG recorder. Pearson correlation coefficients (r) and coefficients of determination (r 2) were calculated to determine the degree of association between the two electronic devices. Two-way repeated measures analysis of variance and Bland-Altman analysis were used to calculate the measurement consistency and agreement, respectively, between the two methods. Effect size was also used to estimate the magnitude of the differences. RESULTS: The number of RRi from asymptomatic adults recorded by the ECG and by the free smartphone application was similar at rest in supine position (13,149 vs. 13,157; P = 0.432) and during orthostatic challenge (10,666 vs. 10,664 P = 0.532). RRi in milliseconds from both devices presented a near perfect correlation in the supine position (r = 0.999; Confidence Interval [CI] at 95%: 0.999-0.999; P < 0.0001) and during orthostatic challenge (r = 0.988; 95% CI: 0.988-0.989; P < 0.0001). A negative bias of -0.526 milliseconds (95% limits of agreement [LoA] from -4.319 to 3.266 milliseconds) was observed in supine position between ECG and the smartphone application. On the other hand, a positive bias of 0.077 milliseconds (95% LoA from -10.090 to 10.240 milliseconds) during the orthostatic challenge was observed. CONCLUSIONS: Our results cross-validated a freeware smartphone application with the ECG-derived reference condition for asymptomatic adults at rest in the supine position and during orthostatic challenge.

Diferenças regionais e custos dos procedimentos de fisioterapia no Sistema Único de Saúde do Brasil, 1995 a 2008 / Regional differences and costs of physical therapy procedures in Brazil's Unified Health System, 1995 to 2008

OBJETIVO: Descrever os atendimentos ambulatoriais fisioterßpicos prestados pelo Sistema Único de Saúde (SUS) no Brasil quanto a sua distribuição geogrßfica, custos, tipos de procedimento e tipos de prestador. MÉTODOS: Foram utilizados dados do Departamento de Informßtica do SUS (DATASUS), referentes ao período de 1995 a 2008, que incluíam a quantidade e o valor dos procedimentos aprovados para pagamento pelas Secretarias de Saúde e a quantidade e o valor dos procedimentos apresentados para pagamento. Os coeficientes de atendimento (CoA) foram calculados dividindo-se o número de atendimentos no ano em uma região pela população estimada no mesmo ano e região. RESULTADOS: O CoA no Brasil em 2008 foi de 0,19 e as regiões Norte e Centro-Oeste apresentaram os menores coeficientes (0,13 e 0,10, respectivamente). Entre 1995 e 2007 houve um crescimento no coeficiente nacional de atendimentos de 33,7 por cento, sendo que a região Norte apresentou o maior aumento, de 143,8 por cento, a Centro-Oeste, de 62,1 por cento, e a Nordeste, de 56,1 por cento. O atendimento nas alterações motoras foi o procedimento mais realizado (61,8 por cento) e os valores de pagamento aprovados foram menores que os apresentados pelos gestores dos serviços em 2008 (10,4 por cento). Estabelecimentos privados com fins lucrativos prestaram 44,5 por cento dos atendimentos fisioterßpicos pagos pelo SUS em 2008. Os estabelecimentos municipais responderam por 26,6 por cento dos atendimentos e os federais por apenas 0,9 por cento. Entre 1995 e 2007, a quantidade de atendimentos oferecidos pelos estabelecimentos municipais cresceu 278,7 por cento. CONCLUSÕES: Observou-se que a oferta de atendimento fisioterßpico ambulatorial pelo SUS ainda é pequena e geograficamente desigual, embora regiões menos desenvolvidas apresentem um maior crescimento no CoA. O SUS remunera inadequadamente os serviços prestados em fisioterapia e ainda o faz, em grande parte, por meio de convênios...

OBJECTIVE: Describe the ambulatory physical therapy treatments provided by the Unified Health System (SUS) in Brazil with regard to their geographical distribution, costs, types of procedure, and types of provider. METHODS: Data from the SUS Information Technology Department (DATASUS) were utilized, drawing from the period from 1995 to 2008, which included the quantity and the value of the procedures approved for payment by the Secretariats of Health and the quantity and value of the procedures presented for payment. The treatment coefficients (CoA) were calculated by dividing the number of treatments in a particular year and region by the estimated population of that region in that year. RESULTS: The CoA in Brazil in 2008 was 0.19 and the North and Center-West regions presented the lowest coefficients (0.13 and 0.10, respectively). Between 1995 and 2007 there was an increase in the national treatment coefficient of 33.7 percent, with the North region showing the largest increase, 143.8 percent; the Center-West 62.1 percent, and the Northeast 56.1 percent. Treatment for motor disorders was the most widely performed procedure (61.8 percent), and the values of payments approved were lower than those presented by the managers of the services in 2008 (10.4 percent). Private for-profit establishments provided 44.5 percent of the physical therapy treatments paid for by the SUS in 2008. Municipal establishments accounted for 26.6 percent of the treatments, and federal establishments for only 0.9 percent. Between 1995 and 2007, the quantity of treatments offered by municipal establishments increased 278.7 percent. CONCLUSIONS: It was observed that the provision of ambulatory physical therapy treatment by the SUS remains small and geographically unequal, although lessdeveloped regions showed a larger increase in the CoA. The SUS remunerates inadequately the physical therapy services provided and continues to do so, in large part, by means of agreements...

[Regional differences and costs of physical therapy procedures in Brazil's Unified Health System, 1995 to 2008]. / Diferenças regionais e custos dos procedimentos de fisioterapia no Sistema Único de Saúde do Brasil, 1995 a 2008.

OBJECTIVE: Describe the ambulatory physical therapy treatments provided by the Unified Health System (SUS) in Brazil with regard to their geographical distribution, costs, types of procedure, and types of provider. METHODS: Data from the SUS Information Technology Department (DATASUS) were utilized, drawing from the period from 1995 to 2008, which included the quantity and the value of the procedures approved for payment by the Secretariats of Health and the quantity and value of the procedures presented for payment. The treatment coefficients (CoA) were calculated by dividing the number of treatments in a particular year and region by the estimated population of that region in that year. RESULTS: The CoA in Brazil in 2008 was 0.19 and the North and Center-West regions presented the lowest coefficients (0.13 and 0.10, respectively). Between 1995 and 2007 there was an increase in the national treatment coefficient of 33.7%, with the North region showing the largest increase, 143.8%; the Center-West 62.1%, and the Northeast 56.1%. Treatment for motor disorders was the most widely performed procedure (61.8%), and the values of payments approved were lower than those presented by the managers of the services in 2008 (10.4%). Private for-profit establishments provided 44.5% of the physical therapy treatments paid for by the SUS in 2008. Municipal establishments accounted for 26.6% of the treatments, and federal establishments for only 0.9%. Between 1995 and 2007, the quantity of treatments offered by municipal establishments increased 278.7%. CONCLUSIONS: It was observed that the provision of ambulatory physical therapy treatment by the SUS remains small and geographically unequal, although less developed regions showed a larger increase in the CoA. The SUS remunerates inadequately the physical therapy services provided and continues to do so, in large part, by means of agreements with private establishments.